Toward a coherent virtual cell model: probing biological world-model coherence in transcriptomic foundation models
NeurIPS 2025 workshop AI for virtual cells and drug discovery (AI4D3)
Can a transcriptomic foundation model tell a real cell from a shuffled one? We propose a model-agnostic test based on synthetic samples and pretraining loss. Models separate real from shuffled cells and show loss barriers between distant cell types, but a coherent world model is far from universal.